Beta peptide distribution 24 h post dose

Beta peptide distribution 24 h post doseMarkus Stoeckli, Dieter Staab, Alain Schweitzer, James Gardiner and Dieter Seebach
J. Am. Soc. Mass Spectrom. 2007, 18, pp. 1921–1924

Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a β-peptide and an α-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the α-peptide control was observed at 1 h post-dose, while retention of the β-peptide was observed for longer than 24 h post-dose.



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