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There might be two explanations:
1) the atd-values for a potential AIF-voxel are out of the expected range. In that case adjust min/max-values in the table below.
2) the data and therefore the atd-parameter maps are of low quality: Movement of the head, to high concentration of CA, low resolution, strong paramagnetic shift effect. If you like, you can send one dataset to us for inspection.
Please note: absolute quantification of perfusion parameters depends critically on the AIF. If it is only a little bit distorted you will obtain values which are far off from what you expected. For this reason we have designed a robust sequence with a very short TE just for the AIF slice (Rausch et al. MRI, 200x).