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Dear Milad, Rob and Junhai

Great conversation. I just started being active in this forum and noticed your conversation. We can certainly help you with these questions if they are still of interest.

I agree with Rob that 0.200ml/min can be too much flow and results in a very wet spray, especially with 50% H20.

My starting point with CHCA sprayed on tissues, is:

<Solvent>70% ACN + 0.1%TFA</Solvent>

Note that this protocol has 70% ACN (instead of 50%). Higher organic content makes the spray evaporate faster. The temperature of 75 Deg C is close to the boiling point of the mixture but should be stable and will evaporate quickly.

Feel free to email me at acreissen(at) if you need more information