Front Page Forums Modifications Modification of Voyager STR for MALDI MSI

  • This topic has 3 replies, 1 voice, and was last updated 18 years ago by Anonymous.
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  • #835
    Markus Stoeckli
    Moderator

    I was often asked for the details of the modification we did on the Voyager STR to make it an imaging instrument. In this topic I’m summarizing our experiences and hope that other will do too.

    First of all, we could use the STR for imaging without any modifications. Ours came with a N2 laser and a LeCroy LSA digitizer, which allowed us to acquire spectra at a rate of 20 Hz. Two factors made us modify the instrument: the lifetime of the plasma cartridge was specified to only 10 Mio shots and we wanted to acquire our images as fast as possible. In effect, we replaced our N2 laser with a powerchip laser from Nanolase. This company belongs now to JDS Uniphase and they still sell the laser. We have a PNV-1025 with 20 uJ pulse energy and a repetition rate of up to 500Hz. We switched also the digitizer to a DP211 board from Aquiris which can keep up with higher repetition rates. All in all, we can now acquire spectra at a rate of up to 160 Hz, depending on the number of data points.

    We have been using the STR in this configuration for about 5 years and are still happy with it. Will it work for you? I don’t know since every STR seems to be different. I guess it’s just a matter of asking ABI for details … no guarantee from my side 😉 .

    markus

    #981
    Anonymous
    Guest

    net-climber,

    How about modification to the laser optics on the DE-STR. I have heard that one needs to change and/or modify the prism to get a tighter beam on to the MALDI plate.
    Any pointers you may have will be helpful.

    ad2005

    #982
    Markus Stoeckli
    Moderator

    Hm, I would guess that one would have to make more changes to the optics than replacing the prism (e.g. set a lense closer to the target, open the beam up and then refocus it again). Bernhard Spengler published his superb optics for the LAMMA 2000 – could give you some ideas.

    Markus

    #1011
    Anonymous
    Guest

    Markus,

    Thanks for your note. I will look into the article you mentioned. That said, I also take comfort in the fact that you have been able to use your STR without any changes. We may decide to upgrade to a faster laser and digitizer similar to your instrument.

    ad2005

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