N. E. Manicke, A. L. Dill, D. R. Ifa, R. G. Cooks
J. Mass. Spectrom. 2010, 45, 223–226

Ambient methods, such as DESI-MS, are used to analyze untreated samples that are typically chemically complex. High-resolution tissue imaging using the orbitrap, as demonstrated here, is one way to improve the selectivity of ambient ionization methods, a necessity for the analysis of complex mixtures.




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